IN VITRO QUALITY ASSESSMENT OF FIVE DIFFERENT BRANDS OF CEFUROXIME AXETIL SUSPENSION SOLD IN AMASSOMA, NIGERIA 

Oraeluno, Jude N^[1*], Obasi, Josephat C^[2], Bunu, Jacob S^[3], Bamigbola, Emmanuel A^[4],Vaikosen, Edebi N^[5], Igwe, Felix U^[6]
Page No.31-39

Health professionals, regulatory agencies for drugs, drug users, and the general public are very worried about therapeutic failure as a result of increasing prevalence of utilizing fraudulent, contaminated, counterfeit, and inferior medications in Nigeria. This study’s objective was to evaluate the in vitro efficacy of five different brands of cefuroxime axetil suspensions sold in Amassoma, Nigeria. They were physically evaluated for indications of manipulation or a broken seal on the primary containers’ cap, as well as for their organoleptic qualities, pH, sedimentation volume, flow rate, viscosity, redispersibility and content of active ingredients/assay using approved protocols. Results revealed that the labels on the suspensions contained all the relevant information, and the containers had not been tampered with to get access to or alter the contents. For color variation, pH, viscosity, flow rate, sedimentation and redispersibility, every brand tested performed well. All of the brands adhered to the cefuroxime axetil content specifications stated on their labels (based on USP). Generally, all the brands are acceptable for distribution and consumption.
Keywords: Quality Assessment, Suspensions, Cefuroxime Axetil.