ACOUSTIC LIQUID HANDLING MASS SPECTROMETRY: A NEW MILESTONE IN LABORATORIES

Sharad Medhe1*, Roopa Rani2
Page No. 1-10

By ruling out other sample injection systems, new acoustic liquid sample introduction technique is developed. The acoustic droplet ejection occurs by focusing sound wave to propel droplets of liquids upward from a source location to a destination which further get ionized and forwarded to mass spectrometer. Smaller amount of sample volume like 2.5 nano litre droplet splits into hundreds of even smaller droplets like femtolitres, which is used to generate the data. Acoustic Droplet Ejection (ADE) and its wide application in mass spectrometry generated full library screen in excess of 2 million compounds in less than six weeks with good precision and accuracy. So far the most important, achieving high scientific impact, ADE is a completely touchless transfer method that shall provide a new milestone in analytical world.
Key words: Acoustic Droplet Ejection, Mass Spectrometry, Echo 650 LIQUID HANDLER