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Phenotypic characterization and susceptibility pattern of Gram negative
bacterial isolates from cases of Central Line Associated Blood Stream Infections
in a tertiary care institute.


Dr. Akhilesh P.S Tomar
Page No. 12-19


Abstract

Background: Resistant and specially Multi Drug Resistant (MDR) Gram negative isolates from the
cases of Central Line Associated Blood Stream Infections (CLABSI) are a serious challenge for the
treatment to clinicians. Present study was undertaken for phenotypic characterization and
susceptibility pattern of Gram negative bacterial isolates from cases of CLABSI in a tertiary care
institute.Materials and Methods: This descriptive cross sectional hospital based study was
conducted in a tertiary care teaching hospital over a period of one and half year from January 2012
to June 2013. CDC’s CLABSI case definitions were used to label a case as CLABSI. Only culture
proven cases, out of clinically suspected was included in the study for evaluation. Results:
Incidence Central Line Associated Blood Stream Infections were (0.31%) with 38 culture positive
cases. The overall rate of CLABSI was 14.64 per 1000 device days with (0.04) device utilization
ratio. Gram negative isolates predominated (79%) over Gram positive isolates (21). Among Gram
negative bacterial isolates from CLABSI, Klebsiella pneumoniae (40%) was the commonest
followed by E. coli (26.66%). %). Rising trends of antimicrobial resistance for common Gram
negative bacterial isolates especially multi drug resistance was noticed.Conclusion: Continuous
surveillance of CLABSI and microbiological reporting of culture isolates is a need of time in the
health care facility.
Key words: Central Line Associated Blood Stream Infections, Gram negative bacterial infection,
Multi Drug Resistant.


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