Epidemiology of hemophilia at the Hospital of Rabat:About 263 cases

A. Chekabab[1] , S. Benkirane [2], A. Masrar[3]
Page No. 174-178

The haemophilia is a constitutional hemorrhagic disease of recessive transmission linked to X
chromosome. The objective of this work is to index the different cases in our service.
Material and methods: During 45 months (April 2008 – December 2012), we account 263
haemophiliac cases diagnosed in our laboratory. Results: Our results interest 263 haemophiliac
cases, which means 198 cases of haemophilia A (75,3%) and 65 cases of haemophilia B (24,7%)
diagnosed. 172 patients have an age less than 15 years old with a median of age as 13 years (limits
9 months - 39 years). The annual incidence of haemophilia is 70 cases. 132 persons had clinical
symptomatology whereas the others were asymptomatic. These symptoms were arthropaty
(62,14%), joint bleed (23,48%), haematoma (5,30%), nosebleeds, bleeding gums (4,54%) and
ecchymosis (4,54%).According to the type of haemophilia: The severe forms of haemophilia (FVIII
or FIX ≤ 1%) are 57,08% (115/198) for haemophilia A and 64,63% (47/65) for haemophilia B.
Discussion: The diagnosis and classification of the haemophilia are possible in routine. Through
the data of literature we propose a diagnostic strategy which makes it possible to consolidate the
analysis of the constitutional haemostasis hemorrhagic diseases in particular of the haemophilia.
Conclusion: The assumption of responsibility of the haemophilia starts with this stage. Our hope is
to be able to extrapolate this study at the national level to set up a national file.
Keywords : Haemophilia, Biological diagnosis.