Jobpcrhttp://www.jobpcr.comJournal of Chemical and Pharmaceutical Research is an online international journal to promote all fields of Chemical Sciences like Organic Chemistry, Green Chemistry, Photochemistry, Inorganic Chemistry, Physical Chemistry, Industrial Chemistry, Biochemistry, Environmental Chemistry, Agricultural and Soil Chemistry, Analytical Chemistry, Polymer Chemistry, Macromolecular Chemistry, Petroleum Chemistry, Forensic Chemistry and Phytochemistry as well as all aspects of Chemical Engineering etc.
Exploring the potential of microbiota transplantation as a novel approach for treating infectious and inflammatory diseases. Journal of Biological ,Pharmaceutical And Chemical ResearchJournal of Biological ,Pharmaceutical And Chemical Research2394-30762023101 Ishan Tiwari Page No.1-24 1 Fecal microbiota transplantation (FMT) is a promising new approach for treating various infectious and inflammatory diseases by restoring a healthy gut microbiome. FMT involves transferring fecal material from a healthy donor into the gastrointestinal tract of a recipient. This book chapter explores the current research on FMT as a treatment for Clostridium difficile infection, inflammatory bowel disease, metabolic syndrome, autoimmune diseases, neurological disorders, and liver disorders. FMT has shown high cure rates for C. difficile infection and has been approved by regulatory agencies for this indication. However, challenges remain in developing FMT as a therapeutic approach for other diseases, including standardization of donor screening and faecal material preparation, regulatory approval, and the need for trained healthcare professionals and infrastructure for FMT administration. Despite these challenges, FMT holds promising potential as a novel and effective treatment approach for a wide range of diseases. This chapter provides an overview of the current state of FMT research and highlights the need for further investigation and development of this innovative therapeutic approach. With continued research and collaboration between researchers, clinicians, and regulators, FMT has the potential to revolutionize the treatment of infectious and inflammatory diseases. Keywords: microbiome, transplant, gut, bacteria, donor, regulation http://www.jobpcr.com/archive-abs.php?arc=380http://www.jobpcr.com/archive/JOBPCR-2023-10-1-110-1-24.pdf
THE HISTORY OF RABIES IN TUNISIA AND THE DEVELOPMENT OF THE RABIES VACCINE Journal of Biological ,Pharmaceutical And Chemical ResearchJournal of Biological ,Pharmaceutical And Chemical Research2394-30762023101 Maha Gasmi1, Ziad Rahma2 Page No. 25-33 1 Over 55,000 people are killed by rabies each year, which continues to be a hazard to worldwide public health. Due to the number of years lost as a result of the disease, rabies is listed as the sixth most significant infectious disease. An illustrious history of more than 120 years has gone into the improvement of rabies vaccination for animals and humans. This review describes the different types of rabies virus vaccines and the development of replication-defective or monocyclic live rabies virus-based vectors for use as single-dose human rabies vaccinations using reverse genetics methods. Key words: Rabies virus, Vaccination, Vaccines, genetics methods. http://www.jobpcr.com/archive-abs.php?arc=381http://www.jobpcr.com/archive/JOBPCR_2023_10-1-111-25-33.pdf
Can intense training improve the physiological, hormonal, and immune responses in older people? Effect of advances in age. Journal of Biological ,Pharmaceutical And Chemical ResearchJournal of Biological ,Pharmaceutical And Chemical Research2394-30762023101 Maha Gasmi1, Ziad Rahma2 Page No.34-38 1 Most research studies investigated the impact of intense training on young and old people, when the deterioration in performance and the decrease in hormonal reactions appeared to happen much earlier, within the fourth decade. In addition, intense training (sprinting and weight training) affects plasma concentrations of hormones and metabolites in 40-year-olds, but what about the immune system? This brief review highlighted the majority of findings about aging and the effect of intense training on physiological, hormonal, and immune responses. Keywords: training, immune response, aging, hormonal response. http://www.jobpcr.com/archive-abs.php?arc=382http://www.jobpcr.com/archive/JOBPCR-2023-10-1-112-34-38.pdf
Anxiolytic, estrogenic and non-toxic effects of sub-acute treatment with Khaya anthotheca (Welw.) C.DC (Meliaceae) decoction in ovariectomized Wistar rats Journal of Biological ,Pharmaceutical And Chemical ResearchJournal of Biological ,Pharmaceutical And Chemical Research2394-30762023101 Zemo Gamo Franklin1*, Djiogue Sefirin1, Tchoupang Nana Edwige2, Awounfack Charline Florence1, Djikem Tadah Rudig Nikanor1, Ndjengue Mindang Elisabeth Louise1 and NJAMEN Dieudonne1. Page No.39-55 1 In Cameroon, Khaya anthotheca (Welw.) C.DC (Meliaceae) is traditionally used to manage central nervous system diseases. Then, the purpose of this study was to evaluate the anxiolytic, estrogenic and toxic effects of sub-chronic treatment with Khaya anthotheca (K. Anthotheca) extract using ovariectomized Wistar rats. For this to be done, 36 rats were ovariectomized and the 6 others were used as SHAM rats. 14 days after ovariectomy, animals were distributed into six groups of 6 animal each. They were treated for 28 consecutive days with distilled water, K. Anthotheca extract (at the doses of 125, 250, and 500 mg/kg BW), estradiol valerate or diazepam. The anxiolytic activity was investigated through the elevated plus-maze (EPM) test; the estrogen-like effects of the extract were determinate on primary estrogens targets and his toxicity was evaluate. As results, in the EPM test, sub-acute treatment with K. Anthotheca extract increased rearing (p 0.01), decrease the weight of fecal boli (p 0.01; p 0.05) and number of grooming (p 0.01). The extract increased (p 0.01; p 0.001) the vaginal epithelia height and stimulated the eosinophil secretion on lumen of alveoli of the mammary gland. In the acute toxicity and sub-acute treatment, the extract showed neither mortality nor exterior toxicity signs (LD50 5000mg/kg). The sub-acute treatment with the extract at the doses of 125, 250 and 500 mg/kg BW did not present any histological modification of liver, kidneys and lungs. These results suggest that K. anthotheca is endowed with anxiolytic and estrogenic properties. Moreover, these results indicate a broad safety margin for K. anthotheca decoction. Keywords: Khaya anthotheca, ovariectomy, estrogenic properties, anxiolytic effects, toxicological profile. http://www.jobpcr.com/archive-abs.php?arc=383http://www.jobpcr.com/archive/JOBPCR-2023-10-1-112-39-55.pdf
Biodiesel From Microalgae: Recent Progress And Key Challenges Journal of Biological ,Pharmaceutical And Chemical ResearchJournal of Biological ,Pharmaceutical And Chemical Research2394-30762023101 Venktesh Kumar Page No.56-62 1 Microalgae biodiesel (BD), which has a substantial amount of lipids and a powerful ability to compensate for CO2, is a potential environmentally friendly fuel. However, the first generation of BD developments intricate and energy-intensive culture, pretreatment procedures, and BD conversion approaches have hindered the commercialization of BD from being accomplished. By meticulously analysing recent technological advancements in the microalgae BD production process, this work resolved the problems and provided encouraging suggestions for future research. Base-catalyzed transesterifications, which were developed from the first generation of BD technologies, are extensively employed in the the microalgal BD synthesis methods nowadays in use. However, the base-catalyzed suffers from the procedure of saponification and a low yield of production since microalgae have a high water content and free fatty acid content. Due to the high yield of microalgae BD synthesis, this technique is not financially viable since it requires substantial pretreatments such drying, esterification to result of fatty acids that are free, and filtration. In an effort to create novel transesterification platforms, new methods that can tolerate contaminants have been suggested, such as dynamically produced non-catalytic transesterifications. Within a minute of a response at 350 C, thermally induced reactions enable the in situ conversion of microalgae lipid into BD (95 wt%). This technique is robust to the presence of water and free fatty acids and does not require a lipid extraction procedure. It was hypothesised that lowering the reaction temperature for thermally induced transesterifications might improve the efficiency of this approach. A pilot study, thorough life cycle assessment, and economic analysis were also recommended in order to explore the economic viability and environmental effects. Keywords: biodiesel, microalgae, environment, economic, biofuels, emission http://www.jobpcr.com/archive-abs.php?arc=385http://www.jobpcr.com/archive/JOBPCR-2023-10-1-114-56.pdf