Histo-pathological alterations of the stomach of guinea pigs following administration of root Aqueous extract of Telfairia Occidentalis

Adeeyo A.O[1a], Yusuf U.A[1b], Adegoke A.A[1c], Dare B.J[2] , Adenowo T.K[3]
Page No 106-112

The root of Telfairia occidentalis is said to contain potent poison which could cause cell death,
despite the usefulness of the leaves, stem, fruits and seeds of this plant. The study investigated the
effects of the aqueous root extract of Telfairia occidentalis on histology of the stomach and blood
serum urea and creatinine level. A total of 15 Guinea pigs were randomly selected into Three (3)
groups A, B and C which were treated with 1ml of distilled water, 100 mg/kg of Telfairia
occidentalis and 200 mg/kg of Telfairia occidentalis for period of six (6) weeks of experiment
respectively. Animals were sacrificed by cervical dislocation after the last administration, Stomach
was excised and fixed in 10% formosaline following abdominal incision and Blood sample was
collected for Serum creatinine concentrations and Serum urea examination. Results obtained
revealed insignificant changes in the serum level of urea and creatinine but histological alteration
in the mucosa lining of stomach caused by irritation was observed in the treated animals when
compared with the control. The root aqueous extract of the Telfairia occidentalis demonstrated a
potent detrimental action on the mucosa lining of the stomach.
Keywords : Stomach, Blood Urea, Blood Creatinine Guinea pigs, Telfairia occidentalis